Professor Juan Carlos Izpisua Belmonte, co-first author Hsin-Kai Liao and colleagues developed a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome, a rare genetic disorder that also afflicts humans. The treatment provides insight into the molecular pathways involved in accelerated aging, as well as how gene therapy can be used to reduce toxic proteins.
Native California medicinal plant may hold promise for treating Alzheimer’s
The medicinal powers of aspirin, digitalis and the anti-malarial artemisinin come from plants. Members of the lab of Professor David Schubert, including senior author Pamela Maher and first author Wolfgang Fisher, discovered a potent neuroprotective and anti-inflammatory chemical in a shrub native to California that may lead to a treatment for Alzheimer’s disease.Read News Release
Vice President, Chief Science Officer and Professor Martin Hetzer, first author Rafael Arrojo e Drigo and colleagues discovered that the mouse brain, liver and pancreas contain populations of cells and proteins with extremely long life spans—some as old as the organism itself. The team’s methods could be applied to nearly any tissue in the body to provide valuable information about the lifelong function of nondividing cells and how cells lose control over the quality of proteins and cell structures during aging.
- Kay Tye – Breaking down the brainInside Salk sat down with Shadel to find out how he became interested in mitochondria, what he is driven by scientifically and what he has learned about aging along the way.
- How to stop a killerPancreatic cancer is one of the most difficult cancers to detect and treat, in part because of an impenetrable "shield" that forms around the tumor. Salk scientists, many of whom have a personal connection to cancer, are leading the charge in new approaches to tackle this deadly disease.
- Travis Berggren – Working at the intersection of biology and technologySenior Staff Scientist Travis Berggren shares his path to Salk and his perspective on how advances in technology facilitate world-changing discoveries in genetics, neuroscience, cancer, immunology, plant biology and other areas.