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Aging
Aging
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Aging

IN THIS ISSUE

Nature Medicine
02/19/2019

Putting the brakes on aging

Professor Juan Carlos Izpisua Belmonte, co-first author Hsin-Kai Liao and colleagues developed a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome, a rare genetic disorder that also afflicts humans. The treatment provides insight into the molecular pathways involved in accelerated aging, as well as how gene therapy can be used to reduce toxic proteins.

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Redox Biology
02/20/2019

Native California medicinal plant may hold promise for treating Alzheimer’s

The medicinal powers of aspirin, digitalis and the anti-malarial artemisinin come from plants. Members of the lab of Professor David Schubert, including senior author Pamela Maher and first author Wolfgang Fisher, discovered a potent neuroprotective and anti-inflammatory chemical in a shrub native to California that may lead to a treatment for Alzheimer’s disease.

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Cell Metabolism
06/06/2019

How old are your organs? To scientists’ surprise, organs are a mix of young and old cells

Vice President, Chief Science Officer and Professor Martin Hetzer, first author Rafael Arrojo e Drigo and colleagues discovered that the mouse brain, liver and pancreas contain populations of cells and proteins with extremely long life spans—some as old as the organism itself. The team’s methods could be applied to nearly any tissue in the body to provide valuable information about the lifelong function of nondividing cells and how cells lose control over the quality of proteins and cell structures during aging.

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