{"id":489,"date":"2026-04-09T12:11:21","date_gmt":"2026-04-09T19:11:21","guid":{"rendered":"https:\/\/insidemultisite.salk.edu\/spring-2026\/?p=489"},"modified":"2026-04-22T08:32:36","modified_gmt":"2026-04-22T15:32:36","slug":"could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness","status":"publish","type":"post","link":"https:\/\/inside.salk.edu\/fall-2020\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\/","title":{"rendered":"Could a dietary supplement make the difference between life and death during illness?\u00a0\u00a0"},"content":{"rendered":"\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary><em>CELL METABOLISM&nbsp;<\/em><br><em>01\/2026&nbsp;&nbsp;<\/em><\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<p>Why is it that two people can develop the same infection but have dramatically different disease trajectories? Salk scientist <a href=\"https:\/\/www.salk.edu\/scientist\/janelle-ayres\/\" target=\"_blank\" rel=\"noreferrer noopener\">Janelle Ayres, PhD<\/a>, and her colleagues discovered that the kidney plays a key role in filtering inflammatory molecules out of the body after an infection, and the amino acid methionine can improve that filtration. Dietary supplementation of methionine was enough to boost kidney performance in mice and protect against inflammation-related wasting, blood-brain barrier dysfunction, and death. The findings highlight how small dietary changes can lead to big impacts in disease outcomes and could support the use of methionine in future treatments for inflammatory conditions, especially in patients with kidney dysfunction.\u00a0<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>\u201cOur findings add to a growing body of evidence that common dietary elements can be used as medicine. By studying these basic protective mechanisms, we reveal surprising new ways to shift individuals that are fated to develop disease and die onto trajectories of health and survival. It may one day be possible for something as simple as a supplement with dinner to make the difference between life and death for a patient.\u201d&nbsp;<\/em><\/p>\n\n\n\n<p><strong>JANELLE AYRES&nbsp;<\/strong><\/p>\n<\/blockquote>\n\n\n\n<p><a href=\"https:\/\/www.salk.edu\/news-release\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\/\" target=\"_blank\" rel=\"noreferrer noopener\">Read news release<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Why is it that two people can develop the same infection but have dramatically different disease trajectories? Salk scientist Janelle Ayres, PhD, and her colleagues discovered that the kidney plays a key role in filtering inflammatory molecules out of the body after an infection, and the amino acid methionine can improve that filtration. Dietary supplementation [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":470,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,24,22],"tags":[],"class_list":["post-489","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discoveries","category-discoveries-home","category-immunobiology"],"blocksy_meta":{"has_hero_section":"enabled","hero_section":"type-2","page_structure_type":"type-3","styles_descriptor":{"styles":{"desktop":"[data-prefix=\"single_blog_post\"] .entry-header .page-title {--theme-font-size:30px;} [data-prefix=\"single_blog_post\"] .entry-header .entry-meta {--theme-font-weight:600;--theme-text-transform:uppercase;--theme-font-size:12px;--theme-line-height:1.3;} [data-prefix=\"single_blog_post\"] .hero-section[data-type=\"type-2\"] {background-color:var(--theme-palette-color-6);background-image:none;--container-padding:50px 0px;}","tablet":"","mobile":""},"google_fonts":{"Albert Sans":["n4","n6"]},"version":6}},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Could a dietary supplement make the difference between life and death during illness?\u00a0\u00a0 - Fall 2020<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inside.salk.edu\/fall-2020\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Could a dietary supplement make the difference between life and death during illness?\u00a0\u00a0 - Fall 2020\" \/>\n<meta property=\"og:description\" content=\"Why is it that two people can develop the same infection but have dramatically different disease trajectories? Salk scientist Janelle Ayres, PhD, and her colleagues discovered that the kidney plays a key role in filtering inflammatory molecules out of the body after an infection, and the amino acid methionine can improve that filtration. Dietary supplementation [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inside.salk.edu\/fall-2020\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\/\" \/>\n<meta property=\"og:site_name\" content=\"Fall 2020\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/salkinstitute\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-09T19:11:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-22T15:32:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inside.salk.edu\/spring-2026\/wp-content\/uploads\/sites\/4\/2026\/04\/26-spring-discoveries-immunobiology-3.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"450\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Salk Institute\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@salkinstitute\" \/>\n<meta name=\"twitter:site\" content=\"@salkinstitute\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Salk Institute\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\\\/\"},\"author\":{\"name\":\"Salk Institute\",\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/#\\\/schema\\\/person\\\/db0e26e1bda71d70b6d1bd4a1a3de862\"},\"headline\":\"Could a dietary supplement make the difference between life and death during illness?\u00a0\u00a0\",\"datePublished\":\"2026-04-09T19:11:21+00:00\",\"dateModified\":\"2026-04-22T15:32:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\\\/\"},\"wordCount\":206,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2026\\\/04\\\/26-spring-discoveries-immunobiology-3.jpg\",\"articleSection\":[\"Discoveries\",\"Discoveries Home\",\"Immunobiology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\\\/\",\"url\":\"https:\\\/\\\/inside.salk.edu\\\/fall-2020\\\/could-a-dietary-supplement-make-the-difference-between-life-and-death-during-illness\\\/\",\"name\":\"Could a dietary supplement make the difference between life and death during illness?\u00a0\u00a0 - 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