{"id":1151,"date":"2026-08-08T18:12:25","date_gmt":"2026-08-09T01:12:25","guid":{"rendered":"https:\/\/inside.salk.edu\/fall-2026\/?p=1151"},"modified":"2026-08-10T21:32:53","modified_gmt":"2026-08-11T04:32:53","slug":"an-internal-liver-clock-orchestrates-fat-secretion","status":"publish","type":"post","link":"https:\/\/inside.salk.edu\/fall-2026\/an-internal-liver-clock-orchestrates-fat-secretion\/","title":{"rendered":"An internal liver clock orchestrates fat secretion"},"content":{"rendered":"\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary><em>PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES&nbsp;<\/em><br><em>03\/2026&nbsp;&nbsp;<\/em><\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most common chronic liver diseases and, when untreated, can progress to cancer, cardiovascular disease, and diabetes. A new study led by <a href=\"https:\/\/www.salk.edu\/scientist\/ronald-evans\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ronald Evans, PhD<\/a>, found that production of the protein FGF1 in the liver varies throughout the day to regulate the timing of fat release from the liver into the bloodstream, acting as a circadian pacemaker for liver fat metabolism.\u00a0<\/p>\n\n\n\n<p>This liver clock ensures fat enters the bloodstream on a precise daily schedule and prevents fat accumulation seen in MASLD. The findings may also help explain why circadian disruption, from shift work to chronic sleep loss, has been linked to metabolic disease. Each mechanistic step uncovered brings scientists closer to therapies grounded not just in symptom management, but also in the fundamental biology of how the body regulates fat.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.salk.edu\/news-release\/how-the-internal-liver-clock-orchestrates-daily-fat-secretion\/\" target=\"_blank\" rel=\"noreferrer noopener\">Read news release<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most common chronic liver diseases and, when untreated, can progress to cancer, cardiovascular disease, and diabetes. A new study led by Ronald Evans, PhD, found that production of the protein FGF1 in the liver varies throughout the day to regulate the timing of fat release from [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,12],"tags":[],"class_list":["post-1151","post","type-post","status-publish","format-standard","hentry","category-discoveries","category-metabolism"],"blocksy_meta":{"has_hero_section":"enabled","hero_section":"type-2","page_structure_type":"type-3","styles_descriptor":{"styles":{"desktop":"[data-prefix=\"single_blog_post\"] .entry-header .page-title {--theme-font-size:30px;} [data-prefix=\"single_blog_post\"] .entry-header .entry-meta {--theme-font-weight:600;--theme-text-transform:uppercase;--theme-font-size:12px;--theme-line-height:1.3;} [data-prefix=\"single_blog_post\"] .hero-section[data-type=\"type-2\"] {background-color:var(--theme-palette-color-6);background-image:none;--container-padding:50px 0px;}","tablet":"","mobile":""},"google_fonts":{"Albert Sans":["n4","n6"]},"version":6}},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>An internal liver clock orchestrates fat secretion - Inside Salk | Fall 2026<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inside.salk.edu\/fall-2026\/an-internal-liver-clock-orchestrates-fat-secretion\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"An internal liver clock orchestrates fat secretion - Inside Salk | Fall 2026\" \/>\n<meta property=\"og:description\" content=\"Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most common chronic liver diseases and, when untreated, can progress to cancer, cardiovascular disease, and diabetes. 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