{"id":68,"date":"2025-11-13T10:12:04","date_gmt":"2025-11-13T18:12:04","guid":{"rendered":"https:\/\/insidemultisite.salk.edu\/spring-2026\/?p=68"},"modified":"2026-08-10T07:29:31","modified_gmt":"2026-08-10T14:29:31","slug":"what-changes-happen-in-the-aging-brain","status":"publish","type":"post","link":"https:\/\/inside.salk.edu\/fall-2026\/what-changes-happen-in-the-aging-brain\/","title":{"rendered":"What changes happen in the aging brain?"},"content":{"rendered":"\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary><em>CELL\u00a0<\/em><br><em>03\/2026\u00a0<\/em><\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<p>Neurodegenerative diseases affect more than 57 million people globally. Though scientists know that aging is a major risk factor for neurodegenerative diseases, the mechanisms underlying its impact remain unclear. But a great place to start is epigenetic change\u2014the way small chemical tags on top of our base genetic code shift over time to alter gene expression. <a href=\"https:\/\/www.salk.edu\/scientist\/joseph-ecker\/\" target=\"_blank\" rel=\"noreferrer noopener\">Joseph Ecker, PhD<\/a>, <a href=\"https:\/\/www.salk.edu\/scientist\/margaritabehrens\/\" target=\"_blank\" rel=\"noreferrer noopener\">Margarita Behrens, PhD<\/a>, and colleagues have created the most comprehensive single-cell atlas of epigenetic changes in the aging mouse brain to date. The new atlas represents eight brain regions and 36 distinct brain cell types, with more than 200,000 single cells profiled across methylation and chromatin conformation assays, plus nearly 900,000 cells captured with spatial transcriptomics. The contents have already revealed clear epigenetic differences across age groups and enabled the researchers to develop novel deep-learning models that predict age-related gene expression changes.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.salk.edu\/news-release\/what-changes-happen-in-the-aging-brain\/\" target=\"_blank\" rel=\"noreferrer noopener\">Read news release<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neurodegenerative diseases affect more than 57 million people globally. Though scientists know that aging is a major risk factor for neurodegenerative diseases, the mechanisms underlying its impact remain unclear. But a great place to start is epigenetic change\u2014the way small chemical tags on top of our base genetic code shift over time to alter gene [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":1357,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,24,13],"tags":[],"class_list":["post-68","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discoveries","category-discoveries-home","category-neuroscience"],"blocksy_meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What changes happen in the aging brain? - Inside Salk | Fall 2026<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inside.salk.edu\/fall-2026\/what-changes-happen-in-the-aging-brain\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What changes happen in the aging brain? - Inside Salk | Fall 2026\" \/>\n<meta property=\"og:description\" content=\"Neurodegenerative diseases affect more than 57 million people globally. Though scientists know that aging is a major risk factor for neurodegenerative diseases, the mechanisms underlying its impact remain unclear. 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