{"id":487,"date":"2026-04-09T12:09:21","date_gmt":"2026-04-09T19:09:21","guid":{"rendered":"https:\/\/insidemultisite.salk.edu\/spring-2026\/?p=487"},"modified":"2026-04-22T08:34:06","modified_gmt":"2026-04-22T15:34:06","slug":"should-younger-and-older-people-receive-different-treatments-for-the-same-infection","status":"publish","type":"post","link":"https:\/\/inside.salk.edu\/spring-2026\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\/","title":{"rendered":"Should younger and older people receive different treatments for the same infection?\u00a0\u00a0"},"content":{"rendered":"\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary><em>NATURE&nbsp;<\/em><br><em>01\/2026&nbsp;&nbsp;<\/em><\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<p>Dealing with an infection isn\u2019t as straightforward as simply killing the pathogen. Our bodies must carefully monitor and steer the immune response to tackle the infection without hurting healthy tissues. If the immune system overreacts and leads to sepsis, this can be more life-threatening than the original infection.&nbsp;<\/p>\n\n\n\n<p>But our bodies change a lot over the course of a lifetime. Do their mechanisms for regulating and tolerating immune activity change, too? Salk scientists, led by <a href=\"https:\/\/www.salk.edu\/scientist\/janelle-ayres\/\" target=\"_blank\" rel=\"noreferrer noopener\">Janelle Ayres, PhD<\/a>, found that younger and older mice with sepsis have distinct paths through sickness. In fact, the mechanisms that young mice used to survive sepsis were the very same mechanisms that caused older mice to die, suggesting that future therapies may be more effective if tailored to the patient\u2019s age. The researchers say new sepsis treatments are especially needed as the antibiotic resistance crisis continues to threaten existing care strategies.\u00a0<\/p>\n\n\n\n<p><a href=\"https:\/\/www.salk.edu\/news-release\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\/\" target=\"_blank\" rel=\"noreferrer noopener\">Read news release<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dealing with an infection isn\u2019t as straightforward as simply killing the pathogen. Our bodies must carefully monitor and steer the immune response to tackle the infection without hurting healthy tissues. If the immune system overreacts and leads to sepsis, this can be more life-threatening than the original infection.&nbsp; But our bodies change a lot over [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":471,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,22],"tags":[],"class_list":["post-487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discoveries","category-immunobiology"],"blocksy_meta":{"has_hero_section":"enabled","hero_section":"type-2","page_structure_type":"type-3","styles_descriptor":{"styles":{"desktop":"[data-prefix=\"single_blog_post\"] .entry-header .page-title {--theme-font-size:30px;} [data-prefix=\"single_blog_post\"] .entry-header .entry-meta {--theme-font-weight:600;--theme-text-transform:uppercase;--theme-font-size:12px;--theme-line-height:1.3;} [data-prefix=\"single_blog_post\"] .hero-section[data-type=\"type-2\"] {background-color:var(--theme-palette-color-6);background-image:none;--container-padding:50px 0px;}","tablet":"","mobile":""},"google_fonts":{"Albert Sans":["n4","n6"]},"version":6}},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Should younger and older people receive different treatments for the same infection?\u00a0\u00a0 - Inside Salk | Spring 2026<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inside.salk.edu\/spring-2026\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Should younger and older people receive different treatments for the same infection?\u00a0\u00a0 - Inside Salk | Spring 2026\" \/>\n<meta property=\"og:description\" content=\"Dealing with an infection isn\u2019t as straightforward as simply killing the pathogen. Our bodies must carefully monitor and steer the immune response to tackle the infection without hurting healthy tissues. If the immune system overreacts and leads to sepsis, this can be more life-threatening than the original infection.&nbsp; But our bodies change a lot over [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inside.salk.edu\/spring-2026\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\/\" \/>\n<meta property=\"og:site_name\" content=\"Inside Salk | Spring 2026\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/salkinstitute\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-09T19:09:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-22T15:34:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inside.salk.edu\/spring-2026\/wp-content\/uploads\/sites\/4\/2026\/04\/26-spring-discoveries-immunobiology-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"450\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Salk Institute\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@salkinstitute\" \/>\n<meta name=\"twitter:site\" content=\"@salkinstitute\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Salk Institute\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\\\/\"},\"author\":{\"name\":\"Salk Institute\",\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/#\\\/schema\\\/person\\\/db0e26e1bda71d70b6d1bd4a1a3de862\"},\"headline\":\"Should younger and older people receive different treatments for the same infection?\u00a0\u00a0\",\"datePublished\":\"2026-04-09T19:09:21+00:00\",\"dateModified\":\"2026-04-22T15:34:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\\\/\"},\"wordCount\":169,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/wp-content\\\/uploads\\\/sites\\\/4\\\/2026\\\/04\\\/26-spring-discoveries-immunobiology-2.jpg\",\"articleSection\":[\"Discoveries\",\"Immunobiology\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\\\/\",\"url\":\"https:\\\/\\\/inside.salk.edu\\\/spring-2026\\\/should-younger-and-older-people-receive-different-treatments-for-the-same-infection\\\/\",\"name\":\"Should younger and older people receive different treatments for the same infection?\u00a0\u00a0 - 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