{"id":73,"date":"2025-11-13T10:12:46","date_gmt":"2025-11-13T18:12:46","guid":{"rendered":"https:\/\/insidemultisite.salk.edu\/spring-2026\/?p=73"},"modified":"2026-04-22T08:30:10","modified_gmt":"2026-04-22T15:30:10","slug":"epigenetic-changes-regulate-gene-expression-but-what-regulates-epigenetics","status":"publish","type":"post","link":"https:\/\/inside.salk.edu\/spring-2026\/epigenetic-changes-regulate-gene-expression-but-what-regulates-epigenetics\/","title":{"rendered":"Epigenetic changes regulate gene expression, but what regulates epigenetics?\u00a0"},"content":{"rendered":"\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary><em>NATURE CELL BIOLOGY&nbsp;<\/em><br><em>11\/2025&nbsp;<\/em><\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<p>All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics, meticulously placed chemical tags that influence which genes are expressed in each cell. Mistakes or failures in epigenetic regulation can lead to severe developmental defects. This creates a puzzling question: If epigenetic changes regulate our genetics, what is regulating them?&nbsp;<\/p>\n\n\n\n<p>Salk scientists, led by biochemist <a href=\"https:\/\/www.salk.edu\/scientist\/julie-law\/\" target=\"_blank\" rel=\"noreferrer noopener\">Julie Law, PhD<\/a>, used plant cells to discover that a type of epigenetic tag called DNA methylation can be regulated by genetic mechanisms. Prior to this study, scientists understood only how DNA methylation could be initiated by other preexisting epigenetic modifications, which didn\u2019t explain how novel methylation patterns could arise. The discovery that the DNA itself can instruct new methylation patterns is a major paradigm shift and helps explain how a cell can modify its epigenetics to grow, respond, and recover. The findings could inform future bioengineering strategies for altering methylation patterns to repair or enhance specific cell functions, with many potential applications in medicine and agriculture.\u00a0<\/p>\n\n\n\n<p><a href=\"https:\/\/www.salk.edu\/news-release\/epigenetic-changes-regulate-gene-expression-but-what-regulates-epigenetics\/\" target=\"_blank\" rel=\"noreferrer noopener\">Read news release<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics, meticulously placed chemical tags that influence which genes are expressed in each cell. Mistakes or failures in epigenetic regulation can lead to severe developmental defects. This creates a puzzling question: If epigenetic changes regulate our [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":474,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,8,24],"tags":[],"class_list":["post-73","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biochemistry-physics","category-discoveries","category-discoveries-home"],"blocksy_meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Epigenetic changes regulate gene expression, but what regulates epigenetics?\u00a0 - Inside Salk | Spring 2026<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inside.salk.edu\/spring-2026\/epigenetic-changes-regulate-gene-expression-but-what-regulates-epigenetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Epigenetic changes regulate gene expression, but what regulates epigenetics?\u00a0 - Inside Salk | Spring 2026\" \/>\n<meta property=\"og:description\" content=\"All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics, meticulously placed chemical tags that influence which genes are expressed in each cell. Mistakes or failures in epigenetic regulation can lead to severe developmental defects. 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