Discoveries
Aging
Aging
Getting older doesn't have to mean getting sicker. We are committed to discovering the fundamental causes of aging and finding new ways to prevent and treat aging-related diseases.

Aging

eLife
11/2019

Alzheimer’s drug candidates reverse broader aging, study shows

Scientists from the lab of Professor David Schubert, including first author Antonio Currais and co-corresponding author Pamela Maher, have shown how the Alzheimer’s drug candidates CMS121 and J147 can slow aging in healthy older mice, blocking the damage to brain cells that normally occurs during aging and restoring the levels of specific molecules to those seen in younger brains. The research points out a new pathway that links normal aging to Alzheimer’s disease.

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Cell Reports
12/2019

Diabetes drug has unexpected, broad implications for healthy aging

Metformin is the most commonly prescribed type 2 diabetes drug, yet scientists still do not fully know how it works to control blood sugar levels. Professor Reuben Shaw, director of Salk’s NCI-designated Cancer Center, and collaborators have used a novel technology to investigate why it functions so well. The findings, which identified a surprising number of biochemical “switches” for various cellular processes, could also explain why metformin has been shown in recent studies to extend health span and life span.

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Protein & Cell
01/2020

Drug combo reverses arthritis in rats

People with osteoarthritis, or “wear and tear” arthritis, have limited treatment options: pain relievers or joint replacement surgery. Research co-led by Professor Juan Carlos Izpisua Belmonte and Salk co-first authors Paloma Martinez-Redondo and Isabel Guillen-Guillen, has discovered that a powerful combination of two experimental drugs reverses the cellular and molecular signs of osteoarthritis in rats as well as in isolated human cartilage cells.

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