Cancer treatments have long been moving toward personalization—finding the right drugs that work for a patient’s unique tumor, based on specific genetic and molecular patterns. Many of these targeted therapies are highly effective but aren’t available for all cancers, including non-small cell lung cancers (NSCLCs) that have an LKB1 genetic mutation. A new study led by Professor Reuben Shaw and collaborators from Northwestern University revealed FDA-approved trametinib and entinostat (which is currently in clinical trials) can be given in tandem to produce fewer and smaller tumors in mice with LKB1-mutated NSCLC. The findings may lead to clinical trials to test the new regimen in humans.
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What’s next for GLPs? Salk scientists are shaping the future of weight-loss medicineSalk researchers are breaking metabolism down piece by piece. Their recent discoveries could help reduce the side effects of GLP-1 drugs and inspire the next generation of weight management therapies.
Science comes alive for high schoolers and educators at SalkSalk’s annual High School Science Day had the highest participation in the event’s history, as 205 excited students were welcomed onto campus. Teachers also had a day of their own at the Ellen Potter Teacher Symposium, learning side-by-side with world-renowned scientists.
Nicola Allen: Neuroscience has a new starAs her recent promotion and awards reflect, Allen has led a paradigm shift in neuroscience by turning the field's spotlight onto astrocytes. These specialized brain cells could be the missing piece to understanding Alzheimer's and other neurological diseases.
Michelle Chamberlain: Bringing together communities old and newChamberlain, whose lifelong commitment to others has shaped her journey to Salk, now serves as Salk’s vice president of External Relations, leading fundraising, communications, community engagement, foundation relations, and stewardship efforts.
Joseph Swift: Saving potatoes, one road trip at a timeSwift, a plant biologist and startup co-founder, had an adventurous upbringing in Australia filled with natural beauty. Today, he uses plant genomics to tackle urgent questions in sustainability and agriculture.
