In this issue
“New technologies have helped advance scientific research yielding vast amounts of data while providing new opportunities for discovery”
NeuroscienceFinding a cause of neurodevelopmental disordersNeurodevelopmental disorders arising from rare genetic mutations can cause atypical cognitive function, intellectual disability and developmental delays, yet it is unclear why and how this happens. Now, Assistant Professor Diana Hargreaves, first author Fangjian Gao and colleagues have identified the molecular mechanism linking a mutation in a complex of proteins to abnormal nervous system development.
CancerMapping normal breast development to better understand cancerBreast cancer is one of the most prevalent cancers, and some forms rank among the most difficult to treat. Professor Geoffrey Wahl, co-first authors Christopher Dravis and Zhibo Ma and colleagues have used state-of-the-art technology to profile cells during normal breast development in order to understand what goes wrong in cancer.
Plant BiologyGetting to the root of how plants tolerate too much ironIron is essential for plant growth, but with heavy rainfall and poor aeration, many acidic soils become toxic with excess iron. This can a affect the availability of staple foods, such as rice. Associate Professor Wolfgang Busch, first author Baohai Li and collaborators have found a major genetic regulator of iron tolerance, a gene called GSNOR.
GeneticsComputational tool lets researchers identify cells based on their chromosome shapeIn the nucleus of every living cell, long strands of DNA are tightly folded into compact chromosomes. Now, thanks to a computational approach developed by Professor Joseph Ecker, first author Jingtian Zhou and colleagues, researchers can use the architecture of these chromosome folds to differentiate cell types.
Immune System BiologyNew target for autoimmune disease could enable therapies with fewer side effectsResearchers—including Professor Ronald Evans, Associate Professor Ye Zheng, first author Christina Chang and colleagues—have discovered a way to stop certain immune system cells from mistakenly attacking the body.
Mapping circuitry for movement A team of Salk scientists led by Professor Martyn Goulding has been awarded $14.3 million over five years by the National Institutes of Health (NIH) to create a high-resolution atlas of how the mouse brain generates and controls skilled forelimb movements, such as reaching and grasping. This effort will provide a […]
Team Salk Cancer Center raised nearly $5,000 in PurpleStride 2019, a walk to end pancreatic cancer held since 2008 by the Pancreatic Cancer Action Network.
Nearly $3 million was raised by last year’s Padres Pedal the Cause cycling event, providing crucial funding for novel cancer research in San Diego, including Salk faculty. Salk Institute scientists Professor Tony Hunter, Assistant Professor Graham McVicker, Professor Joseph Ecker and Helmsley-Salk Fellow Jesse Dixon were among the collaborative teams of researchers and medical professionals […]
Awarded semi-annually by peer review, Salk’s Innovation Grants Program is critical to sustaining emerging science
The program, launched in 2006 by then-Board chair Irwin Jacobs and his wife, Joan, embodies the vision and spirit of the Institute that bears Jonas Salk’s name. The Innovation Grants Program, now supported by a number of forward-thinking donors, is designed to fund out-of-the-box ideas that hold significant promise but may not yet have the track record to attract attention from more traditional funding sources.
On Saturday, September 7, 2019, Salk hosted a Wikipedia Edit-a-thon event, underwritten by the Salk Office of Equity and Inclusion. A total of 60 people from Salk, UC San Diego, Scripps Research and the San Diego community worked together to elevate the profiles of women in STEM (science, technology, engineering and math) on Wikipedia. The […]
On October 30, 2019, Salk Assistant Professor Dannielle Engle shared with the Salkexcellerators group how she creates models of pancreatitis and pancreatic cancer in order to develop more effective diagnostic tools and treatments for these diseases. Salkexcellerators are the next generation of community members who support scientific discoveries at Salk and engage with scientists through […]
On October 23, 2019, the Women & Science Program hosted “Breast Cancer: New insights in research, prevention, survivorship and health care delivery,” a presentation given by Barbara Parker, MD, medical director of Oncology at Moores Cancer Center at UC San Diego. Salk Professor Geoffrey Wahl emceed a panel discussion that followed on the topic of advancements of breast cancer research and treatments and featured Nikki Lytle, a postdoctoral fellow in the Wahl’s Gene Expression Laboratory, Carol Gallagher, Partner with NEA, and Catherine Rivier, Salk Professor Emerita, herself a survivor.
Salk’s Women & Science program hosted an event on July 24, 2019, emceed by Salk Professor Susan Kaech and featuring Professor Kay Tye, who gave a riveting presentation about the neuroscience of seeking pleasure and avoiding pain.