Cancer treatments have long been moving toward personalization—finding the right drugs that work for a patient’s unique tumor, based on specific genetic and molecular patterns. Many of these targeted therapies are highly effective but aren’t available for all cancers, including non-small cell lung cancers (NSCLCs) that have an LKB1 genetic mutation. A new study led by Professor Reuben Shaw and collaborators from Northwestern University revealed FDA-approved trametinib and entinostat (which is currently in clinical trials) can be given in tandem to produce fewer and smaller tumors in mice with LKB1-mutated NSCLC. The findings may lead to clinical trials to test the new regimen in humans.
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Featured Stories
Connecting the dots—From the immune system to the brain and back againBy collaborating across disciplines like genetics, neuroscience, and immunology, Salk scientists are uniquely positioned to lead us into a future of healthier aging and effective therapeutics for Alzheimer’s.
Salk mourns the loss of Joanne ChorySalk Professor Joanne Chory, one of the world’s preeminent plant biologists who led the charge to mitigate climate change with plant-based solutions, died on November 12, 2024, at the age of 69 due to complications from Parkinson’s disease.
Talmo Pereira—From video game bots to leading-edge AI toolsTalmo Pereira is a Salk Fellow, a unique role that empowers scientists to move straight from graduate school to leading their own research groups without postdoctoral training.
Kay Watt—From Peace Corps to plant scienceAt the heart of the Harnessing Plants Initiative is Program Manager Kay Watt who tackles all of the strategy, site operations, budgeting, reporting, communication, and outreach that keep the whole program on track.
Pau Esparza-Moltó—Seeing mitochondria as more than just a powerhousePau Esparza-Moltó, a postdoctoral researcher in Professor Gerald Shadel’s lab, finds comfort in the similarities between his hometown in Spain and San Diego, where he now studies cell-powering mitochondria.
Salk summer programs bring equity and opportunity to the STEM career pipelineThe Salk Institute recently hosted two inaugural events designed to enhance diversity within the scientific community: the Rising Stars Symposium and the Diverse Inclusive Scientific Community Offering a Vision for an Ecosystem Reimagined (DISCOVER) Symposium.