Some molecules are so elusive that scientists require a unique set of tools to capture their structure. That’s precisely how a multi-institutional research team led by Salk scientist Tony Hunter and Salk postdoctoral fellow Rajasree Kalagiri, featured in this issue’s “Next Gen,” defined how antibodies recognize a compound called phosphohistidine—an unstable molecule that’s implicated in certain cancers, such as liver and breast cancer and neuroblastoma. These insights could help researchers understand the molecule’s role in cancer pathways and also enable the design of more efficient antibodies in the future.
Salk team reveals never-before-seen antibody binding, informing both liver cancer and antibody design
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What’s next for GLPs? Salk scientists are shaping the future of weight-loss medicineSalk researchers are breaking metabolism down piece by piece. Their recent discoveries could help reduce the side effects of GLP-1 drugs and inspire the next generation of weight management therapies.
Science comes alive for high schoolers and educators at SalkSalk’s annual High School Science Day had the highest participation in the event’s history, as 205 excited students were welcomed onto campus. Teachers also had a day of their own at the Ellen Potter Teacher Symposium, learning side-by-side with world-renowned scientists.
Nicola Allen: Neuroscience has a new starAs her recent promotion and awards reflect, Allen has led a paradigm shift in neuroscience by turning the field's spotlight onto astrocytes. These specialized brain cells could be the missing piece to understanding Alzheimer's and other neurological diseases.
Michelle Chamberlain: Bringing together communities old and newChamberlain, whose lifelong commitment to others has shaped her journey to Salk, now serves as Salk’s vice president of External Relations, leading fundraising, communications, community engagement, foundation relations, and stewardship efforts.
Joseph Swift: Saving potatoes, one road trip at a timeSwift, a plant biologist and startup co-founder, had an adventurous upbringing in Australia filled with natural beauty. Today, he uses plant genomics to tackle urgent questions in sustainability and agriculture.
