Novel tool confers targeted, stable editing of epigenome in human stem cells
The lab of Juan Carlos Izpisua Belmonte has developed a novel technology to correct disease-causing aberrations in the chemical tags on DNA that affect how genes are expressed. These types of chemical modifications, collectively referred to as the epigenome, are increasingly being considered as important as the genome itself in development and disease. In the May 4, 2017, issue of Science the team described how they used the tool to model mutations in tags associated with colon cancer and to restore the proper tags in stem cells derived from people with Angelman syndrome.
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