The lab of Juan Carlos Izpisua Belmonte has developed a novel technology to correct disease-causing aberrations in the chemical tags on DNA that affect how genes are expressed. These types of chemical modifications, collectively referred to as the epigenome, are increasingly being considered as important as the genome itself in development and disease. In the May 4, 2017, issue of Science the team described how they used the tool to model mutations in tags associated with colon cancer and to restore the proper tags in stem cells derived from people with Angelman syndrome.
- Untangling the mysteries of the spinal cordConverging research and innovative technologies are tackling some of the deadliest motor diseases.
- An interview with Diana HargreavesInside Salk talked with Hargreaves about why she prefers smaller intellectual environments, what excites her about the science she does at the Institute, and how she thinks about being a woman in science.
- Delving into the best of both worlds with Shani SternAs the only electrophysiologist in the lab, Stern uses her engineering expertise to delve into the biological mysteries that most intrigue her, particularly bipolar disorder.