We are rapidly demystifying cancers, exposing the molecular mechanisms underlying tumors and leading the search for the next generation of targeted cancer therapies. We see a future where every cancer and every patient has a cure.

Salk scientists solve longstanding biological mystery of DNA organization

The process by which embryonic stem cells develop into heart cells is complex, involving the precisely timed activation of several molecular pathways and at least 200 genes. Now, Salk Professor Kathy Jones and first author Conchi Estarás, alongside their colleagues, have found a simpler way to go from stem cells to heart cells that involves turning off a single gene, called YAP. The work, which appeared in Genes & Development on December 21, 2017, offers scientists a streamlined method to arrive at functioning heart cells (cardiomyocytes) for both research and regenerative therapies.

Sign up for our monthly newsletter.

Latest discoveries, events & more.