Researchers in Martin Hetzer’s lab found a previously unknown role for a protein called nup98. In addition to helping control how certain molecules move in and out of a cell’s nucleus, nup98 helps direct the development of blood cells, enabling immature blood stem cells to differentiate into mature cell types. The team described their discovery in the December 21, 2017, issue of Genes & Development. Hetzer, first author Tobias Franks and collaborators found that when perturbed, this differentiation process can contribute to certain leukemias, making nup98 a potential target for new cancer therapies.
- Taking on the Big FiveCancer is not like other diseases. Most conditions have external causes—bacteria, viruses, injury—but cancer comes from inside us. Cells go rogue, divide recklessly, invade other tissues and spread throughout the body. They do things normal cells cannot do.
- Dan Lewis – Intense ConnectionFew trustees have had a connection as intensely personal as new Board Chair Dan Lewis, who knows firsthand that cures, indeed, begin with Salk. Thanks to the research of Salk Professor Tony Hunter, the drug Gleevec was born. And thanks to Gleevec, Lewis survived leukemia.
- Jared SmithNeuroscientist and self-described history geek Jared Smith wants to boldly go where no one has gone before. “If this were the 1400s,” asks Smith, “and we were Europeans exploring the world, where is the new world?” For Smith and colleagues in Xin Jin’s lab, the answer is simple: the brain.