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Cellular rejuvenation therapy safely reverses signs of aging in mice

Age may be just a number, but it’s a number that often carries unwanted side effects—from brittle bones and weaker muscles to increased risks of cardiovascular disease and cancer. In new research, Professor Juan Carlos Izpisua Belmonte and co-first author Pradeep Reddy, in collaboration with Genentech, a member of the Roche group, have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states. This approach may provide the medical community with a new tool to restore tissue and overall health by improving cell function and resilience in conditions such as neurodegenerative diseases.

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