Healthy Aging
Healthy Aging
Getting older doesn't have to mean getting sicker. We are committed to discovering the fundamental causes of aging and finding new ways to prevent and treat aging-related diseases.


Nature Aging

Cellular rejuvenation therapy safely reverses signs of aging in mice

Age may be just a number, but it’s a number that often carries unwanted side effects—from brittle bones and weaker muscles to increased risks of cardiovascular disease and cancer. In new research, Professor Juan Carlos Izpisua Belmonte and co-first author Pradeep Reddy, in collaboration with Genentech, a member of the Roche group, have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states. This approach may provide the medical community with a new tool to restore tissue and overall health by improving cell function and resilience in conditions such as neurodegenerative diseases.

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Cell Reports

Cellular regeneration therapy restores damaged liver tissue faster than ever

Mammals can’t typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. But now Professor Juan Carlos Izpisua Belmonte, co-first authors Tomoaki Hishida and Mako Yamamoto, and colleagues have found a way to partially reset liver cells to more youthful states—allowing them to heal damaged tissue at a faster rate than previously observed. The results reveal that the use of reprogramming molecules can improve cell growth, leading to better liver tissue regeneration in mice. The work has implications for treating infection, cancer and genetic liver diseases, as well as metabolic diseases such as nonalcoholic steatohepatitis (NASH).

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