Salk Professor Juan Carlos Izpisua Belmonte, along with first authors Alejandro Ocampo, Paloma Martinez-Redondo, Pradeep Reddy and colleagues, found that intermittent expression of genes normally associated with an embryonic state can reverse the hallmarks of old age. Their approach, which not only prompted human skin cells in a dish to look and behave young again, also resulted in the rejuvenation of mice with a premature aging disease, countering signs of aging and increasing the animals’ lifespan by 30 percent. The early-stage work provides insight both into the cellular drivers of aging as well as possible therapeutic approaches for improving human health and longevity. The Salk researchers believe that induction of epigenetic changes via chemicals or small molecules may be the most promising approach to achieve rejuvenation in humans.
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