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Genetics
Genetics
We are rapidly demystifying cancers, exposing the molecular mechanisms underlying tumors and leading the search for the next generation of targeted cancer therapies. We see a future where every cancer and every patient has a cure.

Genetics

PNAS
07/08/2019

Computational tool lets researchers identify cells based on their chromosome shape

In the nucleus of every living cell, long strands of DNA are tightly folded into compact chromosomes. Now, thanks to a computational approach developed by Professor Joseph Ecker, first author Jingtian Zhou and colleagues, researchers can use the architecture of these chromosome folds to differentiate cell types. The information about each cell’s chromosome structure will give scientists a better understanding of how interactions between different regions of DNA play a role in health and disease.

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Cell Research
08/23/2019

A novel technology for genome-editing a broad range of mutations in live organisms

Professor Juan Carlos Izpisua Belmonte, co-first authors Keiichiro Suzuki, Mako Yamamoto, Reyna Hernandez-Benitez and colleagues, have developed a tool to edit the mouse genome, enabling the team to target a broad range of mutations and cell types. The new genome-editing technology, dubbed SATI, could be expanded for use in a broad range of conditions that arise from gene mutations, such as Huntington’s disease and the premature aging syndrome progeria.

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