When you touch a hot stove, your hand reflexively pulls away; if you miss a rung on a ladder, you instinctively catch yourself. Both motions take a fraction of a second and require no forethought. Professor Martyn Goulding, first author Graziana Gatto and colleagues have mapped the physical organization of cells in the spinal cord that help mediate these and similar critical “sensorimotor reflexes.” The new blueprint of this aspect of the sensorimotor system could lead to a better understanding of how it develops and can go awry in conditions such as chronic itch or pain.Read News Release
New clues why gold standard treatment for bipolar disorder doesn’t work for majority of patients
Lithium is considered the gold standard for treating bipolar disorder (BD), but nearly 70 percent of people with BD don’t respond to it. Now, Salk Professor and President Rusty Gage, co-first authors Renata Santos and Shani Stern, co-corresponding author Carol Marchetto, and colleagues have found that decreased activation of a gene called LEF1 disrupts ordinary neuronal function and promotes hyperexcitability in brain cells—a hallmark of BD. The work could result in a new drug target for BD as well as a biomarker for lithium nonresponsivenessRead News Release
- The aging puzzle comes togetherAging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together.
- Dmitry Lyumkis – A passion for problem solvingAssistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab.
- Pamela Maher – Seeking treatments for Alzheimer’s diseaseFrom having a large garden to investigating compounds that plants make, Staff Scientist Pam Maher talks about how plants inspire her to find treatments for Alzheimer’s disease.
- Rajasree Kalagiri – Bound to phosphohistidineRajasree Kalagiri shares the serendipitous steps along her journey of scientific discovery from southern India to Southern California.