This image shows a 1-millimeter-thick section of mouse brain neurons engineered to express tdTomato, a bright red fluorescent protein derived from Anthozoa (sea coral). Using the Zeiss Z1 Lightsheet microscope—which boasts unprecedented speed and resolution for imaging in 3D—scientists were able to image all of the neurons in the tissue. The multiple colors represent different depths, with warmer colors (red) closer and cooler colors (blue) farther away from the microscope objective. Images such as these help scientists better understand the relationships between different types of brain cells and map the connections between neurons.
This image won the Women & Science Design and Discovery Showcase competition.
Credit: Tong Zhang, PhD, and Uri Manor, PhD
Waitt Advanced Biophotonics Core Facility/Salk Institute