Salk Professor Tony Hunter and colleagues, together with researchers from Switzerland’s University of Basel and University Hospital Basel, discovered a protein called LHPP that acts as a molecular switch to turn off the uncontrolled growth of cells in liver cancer. The tumor suppressor, which could be useful as a biomarker to help diagnose and monitor treatment for liver cancer, could also be relevant for other cancer types. The work appeared in the journal Nature on March 29, 2018.Read News Release
￼￼Organoids reveal how a deadly brain cancer grows
Glioblastoma multiforme (GBM) is an incredibly deadly brain cancer and presents a serious black box challenge. By editing two genes in just a few cells in human cerebral organoids, first author and Senior Research Associate Junko Ogawa and colleagues generated aggressive GBM tumors. This new model could be used to study tumor progression, investigate new drugs or even personalize treatments for patients. The study was published in the journal Cell Reports on April 24, 2018.Read News Release
- The immune system: a question of balanceThe immune system is a powerful biological force—a liquid organ that permeates our bodies. Diverse immune cells are constantly on patrol, hunting for miscreants to roust: bacteria, viruses, tumors, cellular trash. The immune system keeps us safe in a hostile world...
- Rusty GageComplacency has never been part of Fred (Rusty) Gage’s genetic make-up, neither as he has ascended to the ranks of the world’s most renowned neuroscientists nor as he’s taken the helm as President of the Salk Institute...
- Emily ManoogianWhen Emily Manoogian was growing up, “scientist” wasn’t even on her list of potential careers. First Manoogian wanted to be a Broadway tap dancer; then a gymnast; later, a lawyer; and finally, towards the end of high school, a veterinarian.