Discoveries
Immune System Biology
Immune System Biology
In a world full of dangers, from bacterial infections to cancer, our immune system is our fortress. We study the immune system to boost our ability to fight off numerous diseases.

Discovery reveals how cells try to control levels of key HIV protein

Salk Professor Katherine Jones, first author Muyu Xu and colleagues discovered a small molecule called JIB-04 that destroys the HIV protein called Tat, responsible for revving up the virus. The molecule, while itself too toxic to serve as a therapy for HIV, reveals enzymes in host cells that can potentially target Tat and halt this runaway replication process. The work was published in PLOS Pathogens on May 23, 2018.

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