We are rapidly demystifying cancers, exposing the molecular mechanisms underlying tumors and leading the search for the next generation of targeted cancer therapies. We see a future where every cancer and every patient has a cure.


Nature Comm

Maintaining the unlimited potential of stem cells

Embryonic stem cells (ESCs) are the very definition of being full of potential, given that they can become any type of cell in the body. But once they start down the process of turning into a particular type of tissue, they lose their unlimited potential. Assistant Professor Diana Hargreaves, first author Jovylyn Gatchalian and colleagues discovered a new protein complex that keeps the brakes on stem cells, allowing them to maintain their indefinite potential to become any cell type. The new complex, called GBAF, could provide a future target for regenerative medicine.

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Research confirms nerve cells made from skin cells are a valid lab model for studying disease

Professor Joseph Ecker, co-first author Chongyuan Luo and collaborators at Stanford University and Baylor College of Medicine showed that cells induced to grow into nerve cells have molecular signatures matching neurons in the brain.

The study opens the door for better ways to model an individual patient’s disease and could help advance research into gene therapies that are derived from a patient’s own cells.

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