We are working to understand human metabolism and what happens when this biological system breaks down. The problem is more important than ever, given the increasing burden that diabetes and other metabolic dysfunctions have on human health and society.

Salk scientists uncover the health effects of metabolic “magic bullet” protein

The metabolic protein AMPK has been described as a kind of magic bullet for well-being because it can improve cardiovascular health, treat mitochondrial disease and even extend life span.

Now, Professor Reuben Shaw, first author Daniel Garcia and collaborators have developed a new system that lets them study in detail exactly how, where and when AMPK carries out its molecular and therapeutic functions.

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