Salk scientists uncover the health effects of metabolic “magic bullet” protein
The metabolic protein AMPK has been described as a kind of magic bullet for well-being because it can improve cardiovascular health, treat mitochondrial disease and even extend life span.
Now, Professor Reuben Shaw, first author Daniel Garcia and collaborators have developed a new system that lets them study in detail exactly how, where and when AMPK carries out its molecular and therapeutic functions.
- Gerald Shadel explores stressed-out mitochondriaInside Salk sat down with Shadel to find out how he became interested in mitochondria, what he is driven by scientifically and what he has learned about aging along the way.
- The science of agingWhat we know about longevity so far: Minimizing smoking, obesity and overeating while maximizing exercise and social interactions seem to correspond to longer and healthier lives, but not always. While many factors have been touted as panaceas for extending life–everything from adhering to a Mediterranean diet to regularly imbibing red wine–a “fountain of youth” has remained stubbornly elusive.
- Lillian Eichner: Reading the clues to fight cancerEichner began studying cancer while pursuing her PhD at McGill University in Montreal. She was drawn to the Salk Institute for her postdoctoral studies because Reuben Shaw, director of the Salk Cancer Center and a professor in Salk’s Molecular and Cell Biology Laboratory, has taken a new approach to cancer by studying the metabolic pathways of deadly tumors.