Healthy Aging
Healthy Aging
Getting older doesn't have to mean getting sicker. We are committed to discovering the fundamental causes of aging and finding new ways to prevent and treat aging-related diseases.


Nature Chemical Biology

Anti-inflammatory molecules that decline in the aging brain

Aging involves complicated plot twists and a large cast of characters: inflammation, stress, metabolic changes, and many others. Professor Alan Saghatelian, Senior Research Associate Dan Tan, and colleagues, in collaboration with UC San Diego, revealed another factor implicated in the aging process—a class of lipids called SGDGs, which decline in the brain with age and may have anti-inflammatory effects. The finding could have implications for neurodegenerative disorders and other conditions that involve increased brain inflammation.

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Cell Metabolism

Microprotein increases appetite in mice

Salk scientists study how biological processes, like metabolism, can be used to improve cancer treatment outcomes. Tiny proteins, called microproteins, have long been overlooked in obesity and metabolic disease research. Now, Professor Alan Saghatelian and colleagues at UC Irvine have discovered that both brown and white fat are filled with thousands of previously unknown microproteins. They also showed that administering one of these microproteins, called Gm8773, can increase appetite in mice. Their findings may lead to the development of a therapeutic to help people gain weight in certain disease situations, such as during chemotherapy for cancer.

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