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Nature Metabolism

Mitochondria are the “canary in the coal mine” for cellular stress

Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Professor Gerald Shadel, first author Zheng Wu and colleagues have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress or to chemicals that can damage DNA, such as chemotherapy. The results could lead to new cancer treatments that prevent tumors from becoming resistant to chemotherapy.

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Frontiers in Physiology

Mysterious tuft cells found to play role in pancreatitis

The function of tuft cells—cells sensitive to chemical changes—in the pancreas has largely remained a mystery. Now, Professor Geoffrey Wahl, co-first authors Kathleen DelGiorno and Razia Naeem, and colleagues have uncovered how tuft cells form during pancreatic inflammation as well as their surprising role in immunity, using mouse models of pancreatitis. The findings could lead to the development of new biomarkers to test for pancreatitis and pancreatic cancer.

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