We are rapidly demystifying cancers, exposing the molecular mechanisms underlying tumors and leading the search for the next generation of targeted cancer therapies. We see a future where every cancer and every patient has a cure.

Mitochondria are the “canary in the coal mine” for cellular stress

Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Professor Gerald Shadel, first author Zheng Wu and colleagues have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress or to chemicals that can damage DNA, such as chemotherapy. The results could lead to new cancer treatments that prevent tumors from becoming resistant to chemotherapy.

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