Healthy Aging
Healthy Aging
Getting older doesn't have to mean getting sicker. We are committed to discovering the fundamental causes of aging and finding new ways to prevent and treat aging-related diseases.


Redox Biology

New molecule reverses Alzheimer’s-like memory decline

A drug candidate developed by Senior Staff Scientist Pamela Maher and first author Gamze Ates of the Schubert lab, and previously shown to slow aging in brain cells, successfully reversed memory loss in a mouse model of inherited Alzheimer’s disease. The new research also revealed that the drug, CMS121, works by changing how brain cells metabolize fatty molecules known as lipids.

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Method to derive blood vessel cells from skin cells suggests ways to slow aging

Professor and VP/CSO Martin Hetzer, co-first authors Simone Bersini and Roberta Schulte, and colleagues have used skin cells called fibroblasts from young and old patients to successfully create blood vessel cells that retain their molecular markers of age. The team’s approach revealed clues as to why blood vessels tend to become leaky and hardened with age, and lets researchers identify new molecular targets to potentially slow aging in vascular cells.

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