We are working to understand human metabolism and what happens when this biological system breaks down. The problem is more important than ever, given the increasing burden that diabetes and other metabolic dysfunctions have on human health and society.



First immune-evading cells created to treat type 1 diabetes

Professor Ronald Evans, first author and former Staff Scientist Eiji Yoshihara, and colleagues have made a major advance in the pursuit of a safe and effective treatment for type 1 diabetes. Using stem-cell technology, they generated the first human insulin-producing pancreatic cell clusters able to evade the immune system. These “immune shielded” cell clusters controlled blood glucose without immunosuppressive drugs in mice, once transplanted in the body.

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Genes & Development

Common diabetes drug reverses inflammation in the liver

The diabetes drug metformin has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 diabetes. Now, Professor Reuben Shaw, first author Jeanine Van Nostrand and colleagues have shown the importance of specific enzymes in the body for metformin’s function. In addition, the new work showed that the same proteins, regulated by metformin, controlled aspects of inflammation in mice, something the drug has not typically been prescribed for. Apart from clarifying how metformin works, the research has relevance for many other inflammatory diseases.

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